abstract：CONTEXT:The College of American Pathologists periodically surveys laboratories to determine changes in cytopathology practices. We report the results of a 2011 gynecologic cytology survey. OBJECTIVE:To provide a cross-sectional survey of gynecologic cytology practices in 2010. DESIGN:In 2011, a survey was sent to 160...

journal_title：Archives of pathology & laboratory medicine

authors： Crothers BA,Darragh TM,Tambouret RH,Nayar R,Barkan GA,Zhao C,Booth CN,Padmanabhan V,Tabatabai ZL,Souers RJ,Thomas N,Wilbur DC,Moriarty AT

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:The labeling of paraffin blocks and microscopic glass slides in the practice of surgical pathology varies from institution to institution and introduces potential risk of preanalytic error. Currently there are no evidence-based guidelines regarding the uniform labeling of these materials. OBJECTIVE:To develop ...

journal_title：Archives of pathology & laboratory medicine

authors： Brown RW,Della Speranza V,Alvarez JO,Eisen RN,Frishberg DP,Rosai J,Santiago J,Tunnicliffe J,Colasacco C,Lacchetti C,Thomas NE

更新日期：2015-12-01 00:00:00

abstract：CONTEXT:Fine-needle aspiration has been the initial step in the workup of thyroid nodular lesions and has successfully reduced the number of unnecessary surgeries and improved preoperative malignancy detection. However, up to one-third of cases fall in the diagnostically "indeterminate group," which poses a patient-man...

journal_title：Archives of pathology & laboratory medicine

authors： Zhang X

更新日期：2015-12-01 00:00:00

abstract：:A 4-factor prothrombin complex concentrate (4F-PCC), containing therapeutic doses of vitamin K-dependent coagulation factors, was recently licensed in the United States for reversal of vitamin K antagonist therapy. However, given the emergence of several oral anticoagulants for which there are no specific reversal age...

journal_title：Archives of pathology & laboratory medicine

authors： Unold D,Tormey CA

更新日期：2015-12-01 00:00:00

abstract：CONTEXT:Cervical cancer affects 12 000 women in the United States annually. However, despite its prevalence, there remains no good methodology to detect its recurrence. OBJECTIVE:To identify the role of cervicovaginal high-risk human papilloma virus (hr-HPV) testing in predicting cervical cancer recurrence. DESIGN:Th...

journal_title：Archives of pathology & laboratory medicine

authors： Yu MC,Austin RM,Lin J,Beck T,Beriwal S,Comerci JT,Edwards RP,Sukumvanich P,Kelley J,Olawaiye AB

更新日期：2015-11-01 00:00:00

abstract：:Invasive lobular carcinoma of the breast is a relatively common diagnosis. However, other carcinomatous as well as noncarcinomatous neoplasms, either primary or metastatic to the breast, may mimic invasive lobular carcinoma. As treatment may differ, establishing the correct diagnosis is paramount to providing the appr...

journal_title：Archives of pathology & laboratory medicine

authors： Ishikawa MK,Pinsky RW,Smith LB,Jorns JM

更新日期：2015-10-01 00:00:00

abstract：:Levamisole-induced vasculitis is a characteristic cutaneous vasculitis syndrome associated with the use of levamisole-adulterated cocaine. Patients will typically present with a painful, purpuric rash in a retiform or stellate pattern with or without central necrosis involving the extremities, trunk, nasal tip, digits...

journal_title：Archives of pathology & laboratory medicine

authors： Roberts JA,Chévez-Barrios P

更新日期：2015-08-01 00:00:00

abstract：CONTEXT:Hemolyzed specimens delay clinical laboratory results, proliferate unnecessary testing, complicate physician decisions, injure patients indirectly, and increase health care costs. OBJECTIVE:To determine quality improvement practices when hemolysis occurs. DESIGN:We used the College of American Pathologists (C...

journal_title：Archives of pathology & laboratory medicine

authors： Howanitz PJ,Lehman CM,Jones BA,Meier FA,Horowitz GL

更新日期：2015-07-01 00:00:00

abstract：CONTEXT:Cystatin C is becoming an increasingly popular biomarker for estimating glomerular filtration rate, and accurate measurements of cystatin C concentrations are necessary for accurate estimates of glomerular filtration rate. OBJECTIVE:To assess the accuracy of cystatin C concentration measurements in laboratorie...

journal_title：Archives of pathology & laboratory medicine

authors： Eckfeldt JH,Karger AB,Miller WG,Rynders GP,Inker LA

更新日期：2015-07-01 00:00:00

abstract：CONTEXT:Although the value of pharmacogenomics to improve patient outcomes has become increasingly clear, adoption in medical practice has been slow, which can be attributed to several factors, including complicated and expensive testing procedures and required equipment, lack of training by private practice physicians...

journal_title：Archives of pathology & laboratory medicine

authors： Spizz G,Chen Z,Li P,McGuire IC,Klimkiewicz P,Zysling D,Yasmin R,Hungerford W,Thomas B,Wilding G,Mouchka G,Young L,Zhou P,Montagna RA

更新日期：2015-06-01 00:00:00

abstract：CONTEXT:The clinical introduction of new oral anticoagulants (NOACs) has stimulated the development of tests to quantify the effects of these drugs and manage complications associated with their use. Until recently, the only treatment choices for the prevention of venous thromboembolism in orthopedic surgical patients,...

journal_title：Archives of pathology & laboratory medicine

authors： Dias JD,Norem K,Doorneweerd DD,Thurer RL,Popovsky MA,Omert LA

更新日期：2015-05-01 00:00:00

abstract：CONTEXT:Assessment of accuracy and feasibility of whole slide imaging (WSI) for interinstitutional consultation in surgical pathology. OBJECTIVES:To train technical and pathologist staff in WSI technology, establish and evaluate a WSI workflow using training cases and second-opinion consultations, and assess diagnosti...

journal_title：Archives of pathology & laboratory medicine

authors： Jones NC,Nazarian RM,Duncan LM,Kamionek M,Lauwers GY,Tambouret RH,Wu CL,Nielsen GP,Brachtel EF,Mark EJ,Sadow PM,Grabbe JP,Wilbur DC

更新日期：2015-05-01 00:00:00

abstract：:Just as electronic health records are transforming the practice of medicine and health care information management, practicing in the era of the electronic health record offers opportunities, if not imperatives, for pathologists to take on new and "transformative" professional and leadership roles for the organization...

journal_title：Archives of pathology & laboratory medicine

authors： Henricks WH,Wilkerson ML,Castellani WJ,Whitsitt MS,Sinard JH

更新日期：2015-03-01 00:00:00

abstract：:Groove pancreatitis is an uncommon, yet well-described, type of focal chronic pancreatitis, affecting "the groove"-the area between the head of the pancreas, the duodenum, and the common bile duct. Men aged 40 to 50 years are most commonly affected, with a history of alcohol abuse frequently disclosed. Clinical manife...

journal_title：Archives of pathology & laboratory medicine

authors： DeSouza K,Nodit L

更新日期：2015-03-01 00:00:00

abstract：CONTEXT:Turnaround time (TAT) for large or complex surgical pathology specimens is an indicator of efficiency in anatomic pathology and may affect coordination of patient care. OBJECTIVE:To establish benchmarks for TAT and to identify practice characteristics that may influence TAT. DESIGN:Participants in a 2012 Q-Pr...

journal_title：Archives of pathology & laboratory medicine

authors： Volmar KE,Idowu MO,Souers RJ,Karcher DS,Nakhleh RE

更新日期：2015-02-01 00:00:00

abstract：:von Hippel-Lindau (VHL) disease is an autosomal dominant disorder caused by heterozygous mutations in the VHL tumor suppressor gene that is characterized by the occurrence of multiple endocrine and nonendocrine lesions. This review focuses on the endocrine manifestations of VHL disease. Pancreatic neuroendocrine proli...

journal_title：Archives of pathology & laboratory medicine

authors： Cassol C,Mete O

更新日期：2015-02-01 00:00:00

abstract：CONTEXT:Immunohistochemistry has become an indispensable ancillary study in the identification and classification of undifferentiated neoplasms/tumors of uncertain origin. The diagnostic accuracy has significantly improved because of the continuous discoveries of tissue-specific biomarkers and the development of effect...

journal_title：Archives of pathology & laboratory medicine

authors： Lin F,Liu H

更新日期：2014-12-01 00:00:00

abstract：CONTEXT:Ocular surface squamous neoplasia (OSSN) is the most common tumor of conjunctival epithelium associated with risk of permanent visual impairment. It includes conjunctival intraepithelial neoplasia and squamous cell carcinoma. Although American Joint Committee on Cancer-TNM (AJCC-TNM) staging is commonly used in...

journal_title：Archives of pathology & laboratory medicine

authors： Chauhan S,Sen S,Sharma A,Tandon R,Kashyap S,Pushker N,Vanathi M,Sharma N

更新日期：2014-11-01 00:00:00

abstract：:In this article, we review prostatic lymphomas and discuss the differential diagnosis of high-grade malignant neoplasms of the prostate. We illustrate this with a case of a 46-year-old man seen with lower urinary tract obstruction who had diffuse involvement by a high-grade malignancy on prostate biopsy. Morphologic e...

journal_title：Archives of pathology & laboratory medicine

authors： Warrick JI,Owens SR,Tomlins SA

更新日期：2014-10-01 00:00:00

abstract：CONTEXT:Lesions associated with monoclonal light and heavy chains display a variety of glomerular, tubular interstitial, and vascular manifestations. While some of the entities are well recognized, including light and heavy chain deposition diseases, AL (light chain) and AH (heavy chain) amyloidosis, and light chain ("...

journal_title：Archives of pathology & laboratory medicine

authors： Herrera GA

更新日期：2014-10-01 00:00:00

abstract：CONTEXT:Epidermal growth factor receptor (EGFR) mutations have been identified as predictors of response to EGFR tyrosine kinase inhibitors in non-small cell lung cancer. OBJECTIVE:To investigate the relationship of EGFR mutation status to the histologic subtype of adenocarcinoma according to the new International Ass...

journal_title：Archives of pathology & laboratory medicine

authors： Villa C,Cagle PT,Johnson M,Patel JD,Yeldandi AV,Raj R,DeCamp MM,Raparia K

更新日期：2014-10-01 00:00:00

abstract：CONTEXT:Knowledge of human papillomavirus (HPV) status is expected to bias the morphologic evaluation of Papanicolaou (Pap) test results. OBJECTIVE:To characterize Pap test result interpretive bias when the HPV status is known at the microscopic evaluation. DESIGN:Forty HPV-positive liquid-based Pap test results init...

journal_title：Archives of pathology & laboratory medicine

authors： Moriarty AT,Nayar R,Arnold T,Gearries L,Renshaw A,Thomas N,Souers R

更新日期：2014-09-01 00:00:00

abstract：:Placental mesenchymal dysplasia is a rare placental lesion characterized by stem villous cystic dilation and vesicle formation, placentomegaly, and vascular abnormalities. It can be associated with growth restriction, stillbirth, Beckwith-Wiedemann syndrome, and some chromosomal abnormalities, and needs to be distingu...

journal_title：Archives of pathology & laboratory medicine

authors： Pawoo N,Heller DS

更新日期：2014-09-01 00:00:00

abstract：CONTEXT:Clinical laboratory specimens may be rejected as unsuitable for analysis for a variety of reasons and specimen rejection may have significant clinical consequences. OBJECTIVE:To quantify the clinical consequences of specimen rejection and determine the impact of laboratories' policies and practices on these co...

journal_title：Archives of pathology & laboratory medicine

authors： Karcher DS,Lehman CM

更新日期：2014-08-01 00:00:00

abstract：:We report here 2 separate cases in which patients with known low-grade B-cell lymphomas presented with transformed lesions that were CD30⁺, CD4⁺, Epstein-Barr virus negative, and negative or focally weak for a wide range of B-cell, T-cell, and histiocytic/dendritic cell markers. In each case the transformed lymphoma p...

journal_title：Archives of pathology & laboratory medicine

authors： Shaver AC,Ma L,Vnencak-Jones C,Schwarting RS,Fasig KJ,Kim AS

更新日期：2014-08-01 00:00:00

abstract：CONTEXT:Neuroendocrine lung neoplasms are a heterogeneous group of tumors with different clinical behavior and prognosis. OBJECTIVES:To evaluate the expression of p53, KLF4, and p21 in neuroendocrine lung neoplasms and to analyze the influence that expression has on the prognosis of those tumors. DESIGN:All neuroendo...

journal_title：Archives of pathology & laboratory medicine

authors： Naranjo Gómez JM,Bernal JF,Arranz PG,Fernández SL,Roman JJ

更新日期：2014-07-01 00:00:00

abstract：CONTEXT:The results of studies among patients with antithrombin deficiency have suggested that the use of warfarin will increase the level of antithrombin. OBJECTIVE:To reevaluate the effect of warfarin on antithrombin levels using an automated amidolytic method in current use. DESIGN:Antithrombin levels were measure...

journal_title：Archives of pathology & laboratory medicine

authors： Sanfelippo MJ,Engel JM,Onitilo AA

更新日期：2014-07-01 00:00:00

abstract：CONTEXT:Systems-based practice (SBP) is 1 of 6 core competencies required in all resident training programs accredited by the Accreditation Council for Graduate Medical Education. Reliable methods of assessing resident competency in SBP have not been described in the medical literature. OBJECTIVE:To develop and valida...

journal_title：Archives of pathology & laboratory medicine

authors： Vitek CR,Dale JC,Homburger HA,Bryant SC,Saenger AK,Karon BS

更新日期：2014-06-01 00:00:00

abstract：CONTEXT:Advances in RHD genotyping offer an opportunity to update policies and practices for testing weak D phenotypes and administration of Rh immune globulin to postpartum women. OBJECTIVES:To repeat questions from a 1999 College of American Pathologists proficiency test survey, to evaluate current practices for tes...

journal_title：Archives of pathology & laboratory medicine

authors： Sandler SG,Roseff SD,Domen RE,Shaz B,Gottschall JL

更新日期：2014-05-01 00:00:00

abstract：CONTEXT:Genomic medicine is revolutionizing patient care. Physicians in areas as diverse as oncology, obstetrics, and infectious disease have begun using next-generation sequencing assays as standard diagnostic tools. OBJECTIVE:To review the role of pathologists in genomic testing as well as current educational progra...

journal_title：Archives of pathology & laboratory medicine

authors： Haspel RL,Olsen RJ,Berry A,Hill CE,Pfeifer JD,Schrijver I,Kaul KL

更新日期：2014-04-01 00:00:00

abstract：CONTEXT:In the era of targeted cancer therapy, there is growing interest in developing novel therapeutic strategies against endometrial carcinoma, especially its most biologically aggressive variant, serous adenocarcinoma. Several publications have demonstrated that a significant proportion of uterine serous carcinomas...

journal_title：Archives of pathology & laboratory medicine

authors： Buza N,Roque DM,Santin AD

更新日期：2014-03-01 00:00:00

abstract：CONTEXT:In gastric cancer, the significance of perineural invasion remains controversial. Detecting perineural invasion with hematoxylin-eosin staining often leads to misdiagnosis. Labeling nerves by immunohistochemistry greatly assists perineural invasion detection, but it might also be misdiagnosed, because scattered...

journal_title：Archives of pathology & laboratory medicine

authors： Zhou ZH,Xu GF,Zhang WJ,Zhao HB,Wu YY

更新日期：2014-02-01 00:00:00

abstract：CONTEXT:Basal-like breast carcinoma (BLBC) is a distinct molecular subtype of breast carcinoma identified through gene expression profiling studies. OBJECTIVE:To provide the clinical background, the histologic profile, and the immunohistochemical profile of these tumors and discuss the current knowledge of their molec...

journal_title：Archives of pathology & laboratory medicine

authors： Leidy J,Khan A,Kandil D

更新日期：2014-01-01 00:00:00

abstract：CONTEXT:The College of American Pathologists Cancer Case Summaries templates provide a method for including all necessary pathology information in surgical pathology reports with cancer. How effective these templates are at ensuring a complete report, as measured by a separate outside tumor registry, is not known. OBJ...

journal_title：Archives of pathology & laboratory medicine

authors： Renshaw SA,Mena-Allauca M,Touriz M,Renshaw A,Gould EW

更新日期：2014-01-01 00:00:00

abstract：CONTEXT:Assessment of BRAF p.V600E mutational status has become necessary for treatment of patients with metastatic melanoma. Detection of p.V600E mutation by immunohistochemistry was recently reported in several tumor types. OBJECTIVE:To evaluate the interobserver reproducibility of BRAF p.V600E detection by immunohi...

journal_title：Archives of pathology & laboratory medicine

authors： Marin C,Beauchet A,Capper D,Zimmermann U,Julié C,Ilie M,Saiag P,von Deimling A,Hofman P,Emile JF

更新日期：2014-01-01 00:00:00

abstract：CONTEXT:It is recommended that hemoglobin (Hb) A1c (Hb A1c) not be used to assess average glycemia in patients who have altered red blood cell life span. OBJECTIVE:To investigate the frequency of reporting an Hb A1c value for Hb variant samples that do not include Hb A. DESIGN:Hb A1c samples (n = 500) were procured a...

journal_title：Archives of pathology & laboratory medicine

authors： Rhea JM,Koch D,Ritchie J,Singh HV,Young AN,Burgess T,Molinaro RJ

更新日期：2013-12-01 00:00:00

abstract：CONTEXT:The Bethesda System for thyroid fine-needle aspirates does not account for the size of the lesion that is aspirated. OBJECTIVE:To determine whether the size of the lesion would be helpful in order to reduce indeterminate thyroid aspirations. DESIGN:We correlated the results of all thyroid aspirations and surg...

journal_title：Archives of pathology & laboratory medicine

authors： Renshaw AA,Gould EW

更新日期：2013-11-01 00:00:00

abstract：:Clear cell sarcoma shares features with melanoma, but frequently shows EWSR1 rearrangements. It is an aggressive tumor typically occurring in the soft tissues of the extremities, with a gastrointestinal variant with less consistent melanocytic differentiation. It is extremely rare in the head and neck region, with no ...

journal_title：Archives of pathology & laboratory medicine

authors： Kraft S,Antonescu CR,Rosenberg AE,Deschler DG,Nielsen GP

更新日期：2013-11-01 00:00:00

abstract：CONTEXT:Urothelial tumors are rare in young patients. Because of their rarity, the natural history of the disease in young patients remains poorly understood. OBJECTIVE:To understand the pathologic and clinical features of urothelial tumors of the urinary bladder in young patients. DESIGN:We identified 59 young patie...

journal_title：Archives of pathology & laboratory medicine

authors： Stanton ML,Xiao L,Czerniak BA,Guo CC

更新日期：2013-10-01 00:00:00

abstract：CONTEXT:The addition of cetuximab to first-line chemotherapy substantially prolonged survival in patients with advanced non-small cell lung cancer whose tumors expressed high levels of epidermal growth factor receptor (EGFR; immunohistochemistry score of ≥200 on a scale of 0-300). OBJECTIVE:To evaluate the interobserv...

journal_title：Archives of pathology & laboratory medicine

authors： Rüschoff J,Kerr KM,Grote HJ,Middel P,von Heydebreck A,Alves VA,Baldus SE,Büttner R,Carvalho L,Fink L,Jochum W,Lo AW,López-Ríos F,Marx A,Molina TJ,Olszewski WT,Rieker RJ,Volante M,Thunnissen E,Wrba F,Celik I,Stör

更新日期：2013-09-01 00:00:00